The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Stress Fracture: ... => Microscopic fractures ... StressFractures #msk #orthopedics ... #pathophysiology ... #symptoms #signs
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Avulsion or shearing injury ... lateral hip Signs/Symptoms ... msk #diagnosis #pathophysiology ... #signs #symptoms ... #orthopedics
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications
 • Anterior Posterior Compression (APC) -
of Pelvic Ring Fractures ... possible vascular injury ... - Type 1 or 2 injury ... Grades #Grading #Orthopedics ... complications #pathophysiology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
spinal artery injury ... function below injury ... Syndromes #diagnosis #pathophysiology ... #signs #symptoms ... #msk #orthopedics
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD ... #pathophysiology ... endocrinology #peds
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... Incr Skeletal fractures ... Syndrome #genetics #pathophysiology ... #peds #pediatrics
Fracture Healing (and disruptors of this process)
Inflammatory Stage (0-7d)
 • Fracture disrupts local blood vessels ->
(and disruptors ... disrupts local ... #Stages #Orthopedics ... #msk #Staging #pathophysiology ... #diagnosis #disruptors
Adhesive Capsulitis (Frozen Shoulder) - Pathogenesis and Clinical Findings

 • Primary (Idiopathic): Unknown etiology, but associated
Prolonged shoulder injury ... , humeral head fracture ... FrozenShoulder #pathophysiology ... #diagnosis #symptoms
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
metabolites induce injury ... hemorrhagic rash; symptoms ... non-specific viral symptoms ... #Immunization #peds ... #pediatrics #pathophysiology