The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology diagnosis immunology allergic classification hypersensitivityreaction msk definitions grading hypersensitivity types anaphylaxis anticonvulsants complications disruptors fracture fractures healing lowanklesprain management
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Penicillin-induced drug reaction ... , Myasthenia Gravis ... , Graves' Disease ... Dermatitis (ie. reaction ... #Allergic #Reactions
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... reaction. ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... Initial exposure to allergen ... HypersensitivityReaction #Allergy
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
reaction • Type ... reaction • Type ... reaction • Type ... An allergic reaction ... #Allergic #Reactions
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... Primary Reaction ... Secondary Reaction ... after the primary reaction
Classification of Pelvic Ring Fractures: Mechanisms, Clinical Features and Complications • Anterior Posterior Compression (APC) -
cyclist) - APC Grade ... 2.5cm - APC Grade ... ligaments - APC Grade ... auto) - LC Grade ... #Grading #Orthopedics
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... reaction -> Benign ... mediated cytotoxic reaction
Low Ankle Sprain: Pathomechanics and Clinical Findings Grading Ligament Sprains l: Minimal ligament disruption, mild swelling & tenderness,
#Sports #MSK #orthopedics ... #Grading #Grades
Anaphylaxis: Treatments (Acute) Additional Info: • IV steroids may be considered for prevention of late phase reactions.
of late phase reactions ... provided, as well as allergy
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
antibody-mediated immune reaction ... HypersensitivityReaction #Allergy
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