The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... cells recruited Complications ... : • Acute Asthma ... #Immunology #pathophysiology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Acute onset of skin ... exposure to known allergen ... symptoms in the acute ... Signs / Symptoms / Complications ... #Anaphylaxis #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
constipation • Allergic ... MoodStabilizers #Mechanism #SideEffects ... #Pathophysiology ... #Psychiatry #Pharmacology
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
limbs caused by chronic ... bradykinesia/akinesia • Acute ... FirstGeneration #Mechanisms #SideEffects ... #pharmacology #
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings

Ophthalmic Artery Hypertension
Stage 1: Mild/vasoconstrictive
 • Acute and chronic vasospasm
Chronic Hypertensive ... vasoconstrictive • Acute ... and chronic vasospasm ... #Retinopathy #pathophysiology ... signs #symptoms #complications
Cholesteatoma (of middle ear): Pathogenesis and clinical findings
 • Congenital trapping of keratinizing epithelium in middle
Signs / Symptoms / Complications ... inflammation • Acute ... Mastoiditis • Chronic ... Cholesteatoma #MiddleEar #pathophysiology ... signs #diagnosis #complications