The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis pathophysiology psychiatry criteria mnemonic growthhormone amsuicide borderline bpd excess feedbackloop glftap hyperthyroidism macroadenoma masseffects mepeculiar obsessivecompulsive ocpd odd oppositionaldefiant
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Post-Traumatic Stress Disorder (PTSD) Neurochemical abnormalities • Hyper-vigilance • Emotional hyper-arousal • Exaggerated startle reflex • Anxiety
startle reflex • Anxiety ... StressDisorder #PTSD #BehavioralDisorder ... Pathophysiology #diagnosis #symptoms ... #signs #psychiatry
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Obsessive-Compulsive Disorder (OCD): Pathogenesis and clinical findings Psychological Hypothesis • Cognitive behavioral model: Emotional disturbance arising from
maladaptive beliefs and anxiety ... Dysregulation of anxiety ... ObsessiveCompulsive #PersonalityDisorder ... Diagnosis #Psychiatry #Signs ... #Symptoms
Panic Disorder: Pathogenesis and clinical findings Social Factors • Parenting and infant attachment • Childhood illness/abuse •
and hypothalamic-pituitary-adrenal ... carrying anti-anxiety ... Anticipatory Anxiety ... #BehavioralDisorder ... #signs #psychiatry
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Borderline Personality Disorder: Pathogenesis and Clinical Findings Behavioral Traits: • Unstable Relationships - Alternating extremes of idealization
/ irritability/anxiety ... the above with symptoms ... BPD #Borderline #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Schizotypal Personality Disorder (SPD): Pathogenesis and clinical findings Cognitive-Perceptual • Magical thinking - Belief in paranormal or
anhedonia • Social Anxiety ... reference - Anxiety ... #Schizotypal #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Social Anxiety Disorder (SAD) - Pathophysiology Excessive fear of one or more social situations • Safety
Social Anxiety Disorder ... reduce social anxiety ... of Anxiety: Mind ... SocialAnxiety #BehavioralDisorder ... #signs #psychiatry
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