The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... pathophysiology #pituitary
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
time of onset of GH ... GH excess prior ... GH excess after ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology
Schizotypal Personality Disorder (SPD): Pathogenesis and clinical findings
Cognitive-Perceptual
 • Magical thinking - Belief in paranormal or
Personality Disorder (SPD ... familiarity SPD ... #Schizotypal #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Antisocial Personality Disorder (ASPD): Pathogenesis and Clinical Findings
Work & lnterpersonal:
 • Home Life Troubles - Conflict
Personality Disorder (ASPD ... physical assault ASPD ... #Antisocial #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Avoidant Personality Disorder (AVPD): Pathogenesis and Clinical Findings
 • Restraint - Shows excessive restraint in intimate
Personality Disorder (AVPD ... or inferior #AVPD ... #Avoidant #PersonalityDisorder ... Psychiatry #Criteria #Signs ... #Symptoms #Mnemonic
Panic Disorder: Pathogenesis and clinical findings
Social Factors
 • Parenting and infant attachment
 • Childhood illness/abuse
 •
and hypothalamic-pituitary-adrenal ... trigger Physical Symptoms ... Psychological Symptoms ... PanicDisorder #Anxiety #BehavioralDisorder ... #signs #psychiatry