The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Complications: • Acute ... conjunctivitis • Anaphylaxis ... #Immunology #pathophysiology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Acute onset of skin ... exposure to a likely allergen ... exposure to known allergen ... symptoms in the acute ... #pathophysiology
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
Anaphylaxis: Treatments ... (Acute) Additional ... provided, as well as allergy ... Ventolin inhaler #Anaphylaxis ... Treatments #Management #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Mood Stabilizers: Mechanism ... constipation • Allergic ... Stevens-Johnson Syndrome ... MoodStabilizers #Mechanism ... #SideEffects #Pathophysiology
Acute Compartment Syndrome
 • Crush injuries, burns, circumferential constriction to limbs (each containing facially divided muscle
Acute Compartment ... Syndrome • Crush ... local signalling mechanisms ... compartment pressure #Acute ... CompartmentSyndrome #ACS #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained
Early Follicular Phase (Days 0-5)
 • Granulosa cells
continue growing (mechanism ... growth (this is one mechanism ... Polycystic Ovarian Syndrome ... MenstrualCycle #OvarianCycle ... #pathophysiology