The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... metabolic abn #GrowthHormone ... #GH #FeedbackLoop ... #endocrinology ... #pathophysiology
Feedback Loop: Prolactin (PRL)
 • PRL levels exhibit diurnal, menstrual, and age-related variation
 • TRH has
Feedback Loop: Prolactin ... PRL secretion Prolactin ... #PRL #FeedbackLoop ... #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... fraction • HTN #GrowthHormone ... signs #symptoms #endocrinology ... #pathophysiology
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
tumors secrete prolactin ... following order; GH ... the exception of prolactin ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology