The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis retinopathy signs symptoms secondary acute cataracts chronic closedangle diabetes diabetic hypertensive incontinence keratoconus mixed openangle pediatrics peds prematurity retinoblastoma
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Signs / Symptoms / Complications ... • Secondary glaucoma ... Retinoblastoma #pathophysiology ... #ophthalmology
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
Acute Closed Angle Glaucoma ... present with early glaucoma ... Signs / Symptoms / Complications ... #pathophysiology ... #ophthalmology
Diabetic Retinopathy: Pathogenesis and clinical findings Mild Non-proliferative DR • Outpouchings of the weakened capillary walls or
Retinopathy #Diabetes #ophthalmology ... #diagnosis #complications ... #pathophysiology
Chronic Hypertensive Retinopathy: Pathogenesis and clinical findings Ophthalmic Artery Hypertension Stage 1: Mild/vasoconstrictive • Acute and chronic vasospasm
#Retinopathy #pathophysiology ... #ophthalmology ... signs #symptoms #complications
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
Incr PVR if a complication ... Incontinence #Mixed #Pathophysiology ... Signs #Symptoms #Urology
Keratoconus: Pathogenesis and Clinical Findings Genetics • Family history of keratoconus • Ehlers-Danlos syndrome • Down, Turner,
Signs / Symptoms / Complications ... #Keratoconus #pathophysiology ... #ophthalmology
Secondary Glaucoma: Pathogenesis and Clinical Findings Open-Angle Secondary Glaucoma: • Pre-trabecular defect -> Aqueous outflow is obstructed
Secondary Glaucoma ... Open-Angle Secondary Glaucoma ... => Secondary glaucoma ... #pathophysiology ... #ophthalmology
Cataract: Pathogenesis and clinical findings Increased Age (most common) -> Ultraviolet light, radiation, toxins ->Denaturation and abnormal
angle closure glaucoma ... #cataracts #pathophysiology ... #ophthalmology
Retinopathy of Prematurity: Pathogenesis and clinical findings Increased metabolic demand of growing eye -> Excessive VEGF production ->
-> Neovascular complications ... peds #pediatrics #pathophysiology ... #ophthalmology
Primary Open-Angle Glaucoma: Pathogenesis and Clinical Findings • Risk factors -> Incr IOP, Incr age, African-American
Primary Open-Angle Glaucoma ... Primary Open-Angle Glaucoma ... Secondary #OpenAngle #Glaucoma ... #pathophysiology ... #ophthalmology
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