The Calgary Guide to Understanding Disease @TheCalgaryGuide
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allergy diagnosis hypersensitivityreaction immunology signs sle symptoms systemic classification definitions gastrointestinal manifestations msk mucocutaneous musculoskeletal reactions type1 type2 type4 typei
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
: Summary Type ... conjunctivitis Type ... • Ex: Systemic Lupus ... Erythematosus, ... #Reactions #Types
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Type I Hypersensitivity ... cells recruited Complications ... Anaphylaxis #TypeI ... #Type1 #HypersensitivityReaction ... #pathophysiology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... : • Systemic Lupus ... • Erythematosus ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Erythematosus ... Gastrointestinal #Complications ... #pathophysiology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
Type IV Hypersensitivity ... mediated; exposure to allergen ... Allergic reaction ... ivy) #TypeIV #Type4 ... #Immunology #pathophysiology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... #Erythematosus ... Musculoskeletal #Complications ... #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... signs #symptoms #complications
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Type II Hypersensitivity ... cell surfaces #Type2 ... #Type2 #HypersensitivityReaction ... #Allergy #Immunology ... #pathophysiology
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