The Calgary Guide to Understanding Disease @TheCalgaryGuide
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pathophysiology allergy complications signs sle symptoms classification erythematosus hypersensitivity reactions systemic types comparison degenerative gastrointestinal hypersensitivityreaction immunology inflammatory jointdisease jointpain
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... Ex: Antibiotic allergies ... • Ex: Systemic Lupus ... Classification #Diagnosis ... #Definitions
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
clinical findings Definition ... : • Systemic Lupus ... HypersensitivityReaction #Allergy
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Systemic #Lupus ... signs #symptoms #diagnosis
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity: Definitions ... leading to an allergic ... leading to an allergic ... Classification #Diagnosis ... #Definitions
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... Erythematosus #SLE #MSK ... signs #symptoms #diagnosis
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... Phenomenon #Lupus ... pathophysiology #diagnosis
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
Rheumatoid arthritis, Lupus ... Comparison #Versus #MSK ... JointDisease #JointPain #Diagnosis
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