Ravi Singh K @rav7ks
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Academic Hospitalist and Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Thrombosis vs Arterial ... • Nephrotic Syndrome ... Fat Emboli ARTERIAL ... THROMBOSIS Arterial ... pathophysiology #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... capillary leak syndrome ... Amyloidosis and monoclonal ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Idiopathic monoclonal ... Cold Agglutinin Syndrome ... malignancy (CLL) - Monoclonal ... Such As: • IgM monoclonal ... hemolytic #anemia #hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... aneurysm: Causes arterial ... - TMA: TTP - Arterial ... , HUS, DIC #Arterial ... Diagnosis #clots #hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... abnormal intact monoclonal ... : • Serum IgM monoclonal ... MGUS: • Serum monoclonal ... #Significance #hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... 20% Sjögren's syndrome ... Cryoglobulins: - Single monoclonal ... - Composed of monoclonal
Pustular Skin Lesions - Differential Diagnosis Framework

What are pustules?
• Pustules < 5-10 mm + pus
• Material
10 mm + pus • Material ... Bacterial folliculitis ... SAPHO syndrome ( ... Sweet syndrome ... Differential #Diagnosis #Dermatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... Vascular Disease: Arterial ... tests in Behcet syndrome ... adenopathy (PFAPA) syndrome ... refractory disease : monoclonal
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... gangrenosum • Bacterial ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
Stroke Volume / Arterial ... less compliant arteries ... of developing atrial ... mmHg developed atrial ... Acute Coronary Syndrome