Ravi Singh K @rav7ks
1.2M 757 370
Academic Hospitalist and Associate Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Hopkins Medicine Clerkship Site Director, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Causes of Orthopnea - Differential Diagnosis Framework

 • Fear and Anxiety
 • Pleural Effusion
 • Ascites
Causes of Orthopnea ... • Ascites • COPD ... • Pulmonary Edema ... - CNS lesion: ALS ... Differential #Diagnosis #Causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
in 1923 Low ALP ... Most cases diagnosed ... nephrocalcinosis • CPPD ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
wasting, anemia, edema ... , or any other cause ... weeks #Scurvy #Pathophysiology ... #VitaminC #AscorbicAcid ... #Pathophysiology
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
and Hypoxia - Pathophysiology ... Phosphate is a cause ... phosphorus is seen in COPD ... patients with COPD ... respiratory #hypoxia #pathophysiology
PFAPA Syndrome - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis

EPIDEMIOLOGY:
PFAPA is the most common syndrome entailing
fever (FMF) PATHOPHYSIOLOGY ... : The exact cause ... abdominal pain, and edema ... It causes the absolute ... known pathogenic cause