Ravi Singh K @rav7ks
1.2M 757 370
Academic Hospitalist and Associate Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Hopkins Medicine Clerkship Site Director, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
Cardiovascular Causes ... failure - CAD/ACS ... - Asthma - COPD ... syndrome Other Causes ... Guillain Barre - ALS
Causes of Orthopnea - Differential Diagnosis Framework

 • Fear and Anxiety
 • Pleural Effusion
 • Ascites
Causes of Orthopnea ... • Ascites • COPD ... - CNS lesion: ALS ... Differential #Diagnosis #Causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... nephrocalcinosis • CPPD ... adult population: also ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... Hypotension • AMS ... Differential #Diagnosis #Algorithm ... #Pathophysiology ... #Nephrology #Chloride
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... to liver than ALT ... • AST/ALT > ALP ... differential #diagnosis #algorithm
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... ALP: - Enzymes ... - Increased ALP ... Intestine - Other causes ... Differential #Diagnosis #Algorithm
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Lateral Sclerosis (ALS ... lateral sclerosis Pathophysiology ... - Causes progressive ... Escorial criteria uses ... Lateral #Sclerosis #neurology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Hyperviscosity, TTP, APLS ... considered in all ... cases of arterial ... coagulation and other causes ... Venous #Arterial #pathophysiology
Uncommon Causes of Noncardiogenic Pulmonary Edema (NCPE) - Differential Diagnosis Framework

High Altitude Pulmonary Edema:
 • Accumulation
Uncommon Causes ... epilepticus • Pathophysiology ... Pulmonary Edema: • Pathophysiology ... The predominant pathophysiologic ... • Pathophysiology
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
and Hypoxia - Pathophysiology ... Phosphate does also ... Also ↓ Phosphate ... is a cause of refractory ... respiratory #hypoxia #pathophysiology