Ravi Singh K @rav7ks
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Academic Hospitalist and Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Common Variable ... • Chronic lung ... lymphocytic interstitial lung ... autoimmune hemolytic anemia ... hypogammaglobulinemia #immunology #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... Neutropenia - recurrent infections ... Idiopathic • Infections ... Treatment: ... #oncology #hematology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
polymicrobial infection ... • Most common ... Leukocytosis, anemia ... hemorrhage • Treatment ... several months of treatment
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
symptoms - most common ... • Symptoms of anemia ... • hemolytic anemia ... disease #hemolytic #anemia ... #hematology #diagnosis
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Mycobacteria (NTM) Infections ... infections • ... Hematologic malignancy ... Bone Marrow - Anemia ... differential #diagnosis #infectiousdiseases
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Lung Infections ... dyspnea • (Less common ... 100% of cases), anemia ... #Infections #HIV ... differential #diagnosis #infectiousdiseases
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... weeks without infection ... • Neutropenia, anemia ... microglobulin Treatment ... #hematology
Ear Pain (Otalgia) - Differential Diagnosis Framework

Primary Otalgia 
 - Pain that originates from the ear
associated with infection ... otalgia Most Common ... otalgia Most Common ... subdural hematoma, lung ... Otalgia #Ear #Pain #Otology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
petechiae) • Frequent infections ... Most common cytopenia ... • Parvovirus infection ... Syndromes #diagnosis #hematology ... #oncology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
droppings • Most common ... Histoplasmosis Treatment ... change in the lungs ... nails, bronchi, lungs ... ) #Mycoses #InfectiousDiseases