Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A, E, B, D, EBV, CMV, HSV • Toxic: Alcohol, Medication, Recreational Drugs, Mushrooms • Hereditary: Hemochromatosis, Wilson's Disease, Alpha-1 Antitrypsin • Other: NAFLD, Autoimmune hepatitis, Acute biliary obstruction, HELLP Syndrome, Celiac Disease Hepatocellular - Vasculature • Hepatic Vein: Budd-Chiari, Congestion/CHF • Hepatic Artery: Shock Liver, Thrombus, Vasospasm Cholestatic - Intrahepatic • Obstructive: Malignancy, 1° PBC, 1° PSC, Cystic Fibrosis, Infiltrative Disease, Sickle Cell, VOD, GVHD • Toxic: Medication, Pregnancy, Alcoholic Hepatitis, TPN • Infectious: Sepsis, Viral Hepatitis, TB Cholestatic - Extrahepatic • Biliary: Choledocholithiasis, Stricture, Malignancy, Liver Fluke, Ascariasis, Choledochal Cyst • Pancreatic: Pancreatitis, Pancreatic Pseudocyst, Cancer - Sophia Hayes MD @Sophia_Hayes_MD #Liver #Injury #Differential #Diagnosis #Causes #Acute #algorithm #hepatology