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differential rheumatology antibodies classification diseases syndromes acute aki algorithm ana antineutrophil antinuclear associations autoantibodies bee cryoglobulinemia cryoglobulins inflammatory injury kidney
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... • Sjögren syndrome ... Vasculitis: • ... Microscopic polyangiitis ... #antibodies #diagnosis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- Vasculitis, e.g ... - Vasculitis, e.g ... Microscopic polyangiitis ... U1-RNP antibody ... Associations #diseases #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... ): • Microscopic ... tract, and often causes ... • Cogan Syndrome ... Dx: GPA, EGPA, microscopic
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
Inflammatory causes ... encephalomyelitis • MOG antibody-associated ... spectrum disorder • ANCA-associated ... vasculitides • ... #differential #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... dipstick, urine microscopy ... osmolarity If cause ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... - GPA, EGPA, microscopic
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... vasculitis (AAV ... antibody, Anti-GBM ... antibody • Urine ... Goodpasture's cause
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... )): Microscopic ... tract, and often causes ... • Cogan syndrome
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