22 results
Small Vessel Vasculitides
 • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
Small Vessel Vasculitides ... retroorbital mass) • Microscopic ... Interstitial lung disease ... Sjogren's syndrome ... #vasculitis #differential
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
small vessels - ANCA-associated ... granulomatosis - microscopic ... Churg-Strauss syndrome ... drugs, malignomas, and ... - Sjögren syndrome
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... vasculitis (Eosinophilic ... polyangiitis, Microscopic ... vasculitis, Behcet ... #differential #
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
La) - Sjogren's syndrome ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... Microscopic polyangiitis ... Goodpasture's syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... ): • Microscopic ... • Cogan Syndrome ... Differential ... Dx: GPA, EGPA, microscopic
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
the Skin - Differential ... • ANCA Associated ... : - Microscopic ... : • Behcet Disease ... • Cogan syndrome
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
Hematuria - Differential ... basement membrane disease ... Diagnostic of GN or vasculitis ... of glomerular disease ... #Hematuria #Differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... cases • Sjögren syndrome ... Vasculitis: • ... Microscopic polyangiitis ... Jcortesizaguirr #ANA
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Differential Diagnosis ... dipstick, urine microscopy ... Glomerulonephritis / Vasculits ... Abdominal compartment syndrome ... • Cardio-renal syndrome
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... reticularis Differential ... Diagnosis: Vasculitis ... Polyarteritis nodosa • Microscopic ... • Goodpasture syndrome