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diagnosis rheumatology causes algorithm nephrology dermatology pulmonary renal acute aki ana antinuclear diseases rash vasculitides anca antibody antineutrophil associations autoantibodies
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
Small Vessel Vasculitides ... retroorbital mass) • Microscopic ... and Sjogren's syndrome ... • IgA vasculitis ... #vasculitis #differential
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis Involving ... the Skin - Differential ... Associated: - Microscopic ... Disease • Cogan syndrome ... #rheumatology #differential
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
La) - Sjogren's syndrome ... disease c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... Microscopic polyangiitis ... #rheumatology #antibodies
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
Hematuria - Differential ... urine sediment Microscopic ... urine sediment by microscopy ... Diagnostic of GN or vasculitis ... #Hematuria #Differential
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... ANCA-positive vasculitis ... polyangiitis, Microscopic ... ANCA-negative vasculitis ... #differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... PR3-ANCA): • Microscopic ... • Cogan Syndrome ... Dx: GPA, EGPA, microscopic ... C-ANCA) pattern: antibodies
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
of Hemoptysis - Differential ... • Pulmonary Vasculitis ... Goodpasture's Syndrome ... polyangiitis / microscopic ... #Hemoptysis #Differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... cases • Sjögren syndrome ... ANCA-Associated Vasculitis ... : • Microscopic ... Renal-limited vasculitis
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... Infection - Vasculitis ... - Autoimmune Vasculitis ... Sjogren's, GPA, EGPA, Microscopic ... of antinuclear antibodies
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria - Differential ... • Fanconi's syndrome ... • Anti-GBM antibodies ... polyangiitis (GPA) / microscopic ... Proteinuria #Nephrology #Differential
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