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diagnosis differential vasculitis antibodies classification ana antinuclear diseases acute aki algorithm antibody antineutrophil associations autoantibodies causes cryoglobulinemia cryoglobulins cutaneous dermatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... cases • Sjögren syndrome ... Vasculitis: • Microscopic ... 80-90%) > MPO - ANCA ... antibodies #diagnosis #rheumatology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal Syndrome ... Pauci-Immune: - ANCA-positive ... polyangiitis, Microscopic ... testing: anti-ANCA ... differential #diagnosis #nephrology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
La) - Sjogren's syndrome ... Graves' disease c-ANCA ... granulomatosis p-ANCA ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Glomerulonephritis / Vasculits: ANCA ... Abdominal compartment syndrome ... • Cardio-renal syndrome ... Differential #Diagnosis #nephrology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
small vessels - ANCA-associated ... granulomatosis - microscopic ... Churg-Strauss syndrome ... - Sjögren syndrome ... Vessels #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis • ANCA ... Associated: - Microscopic ... Disease • Cogan syndrome ... #dermatology #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
) ANA or Anti-NucIear ... Using fluorescence microscopy ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... 20% Sjögren's syndrome ... DDX: • ANCA (Antineutrophil ... vasculitis - GPA, EGPA, microscopic ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Mucocutaneous lymph node syndrome ... )): Microscopic ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome ... Differential #Diagnosis #Rheumatology
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