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differential algorithm management causes gitelman hyponatremia alkalosis blood casts hematuria hypernatremia hypokalemia kidney metabolic microscopy pathophysiology renal urinary workup acute
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome • Urine Chloride • Urine Ca/Cr ratio Dr. Krithika
from Bartter syndrome ... • Urine Chloride ... • Urine Ca/Cr ... Bartter #Algorithm #nephrology ... #hypokalemia #diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
, Gitelman syndrome ... Urine chloride is ... sodium is typically ... #nephrology #differential ... #diagnosis
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
- Differential Diagnosis ... disease - Alport syndrome ... pain hematuria syndrome ... - RBC casts → Diagnostic ... #nephrology #renal
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
: Differential Diagnosis ... volume contracted: urine ... volume expanded: urine ... #Differential #Diagnosis ... #Causes #nephrology
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... Pathophysiology #nephrology ... #diagnosis
Volume Based Approach to Hyponatremia Hypovolemic, Serum uric acid >4 • Urine Na <20: Extra-renal losses •
uric acid >4 • Urine ... Cirrhosis, Nephrotic syndrome ... • Urine Na > 30 ... Hyponatremia #algorithm #diagnosis ... #sodium #low #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... microscopy / urinary ... • Cardio-renal syndrome ... #Differential #Diagnosis ... #nephrology #causes
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... Hypocalciuria (spot urine ... Rhabdomyolysis Treatment ... #diagnosis #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Algorithm 1) Check Urine ... , Cushing syndrome ... Workup #Algorithm #nephrology ... #sodium
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... • Fanconi's syndrome ... polyangiitis (GPA) / microscopic ... #Proteinuria #Nephrology ... #Differential #Diagnosis
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