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algorithm causes rheumatology management workup oncology hemolytic classification symptoms pancytopenia rbc cirrhosis erythematosus lupus macrocytic mcv mnemonic sle syndrome systemic
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... vs Hypocellular MDS ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Can progress to MDS ... #Anemia #diagnosis ... management #treatment #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... Diagnosis Algorithm ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Non-hemolytic: ACD, Aplastic ... Non-megaloblastic: Liver disease ... Reticulocytosis, MDS ... #Diagnosis #hematology
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Deficiency • MDS ... Hypothyroid • Liver Disease ... #differential # ... diagnosis #algorithm ... #hematology #workup
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential ... Diagnosis Algorithm ... Signs of anemia ... #Differential # ... #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
FISH • Acquired Aplastic ... Anemia • Hypoplastic ... MDS • Congenital ... Metastatic Disease ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
FISH • Acquired Aplastic ... Anemia • Hypoplastic ... MDS • Congenital ... Metastatic Disease ... #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... #hematology #diagnosis
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