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diagnosis management algorithm differential syndrome workup chronic cll leukemia lymphocytic myelodysplastic pancytopenia activation arteritis autoinflammatory cancer e1 erythematosus gca giantcell
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... vs Hypocellular MDS ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Illness Script Signs ... Treatment: • Consider ... Can progress to MDS ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... only curative treatment ... Myelodysplastic #Syndrome #MDS ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Non-hemolytic: ACD, Aplastic ... anemia, CKD • ... Reticulocytosis, MDS ... Matthew Ho, MD ... Differential #Diagnosis #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... myelodysplastic syndrome (MDS ... myelodysplastic syndrome (MDS ... • giant cell arteritis ... Autoinflammatory #Somatic #rheumatology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
FISH • Acquired Aplastic ... Anemia • Hypoplastic ... MDS • Congenital ... Diagnosis #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
FISH • Acquired Aplastic ... Anemia • Hypoplastic ... MDS • Congenital ... Diagnosis #Algorithm #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes (MDS ... platelets) • MDS ... precursors MDS ... • Aplastic Anemia ... Syndromes #diagnosis #hematology
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
present, symptoms, signs ... Splenomegaly Treatment ... transformation into AML or MDS ... • Treatment is ... #hematology
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