40 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... - pulmonary opacities ... sepsis), PE, DAH, CHF ... APML #diagnosis #management
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Decompensated CHF ... • Obstructive: Pulmonary ... Abdominal compartment syndrome ... Dehydration Shock Treatment ... #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... WBC >100k, + lab signs ... organ damage • Treatment ... acid, Elevated Cr ... TLS #diagnosis #management
Heart failure with Reduced Ejection Fraction (HFrEF)
Clinical Presentation
1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
Fraction (HFrEF) Clinical ... More Specific Signs ... Less Specific Signs ... → no signs of CXR ... heartfailure #diagnosis #management
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Pathogenesis and clinical ... - Significant weight ... overload -> - CHF ... - Pulmonary ... pathophysiology #symptoms #signs
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... : 33% • Treatment ... : Age>60, CKD, CHF ... fluid balance, and CXR ... with pulmonary
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
meningococcal, H1N1) Clinical ... Guillain-Barre Clinical ... Treatment: • Plasmapheresis ... #diagnosis #management ... #treatment #neurology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Clinical Picture ... test - Cogan sign ... - Peek sign ... Gravis #diagnosis #management ... #neurology
Bronchiectasis - Summary

What?
• Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
• Mounier-Kuhn syndrome ... dyskinesia • Young syndrome ... Nasal polyps and signs ... Physical stigmata of cor ... mycobacteria Treatment
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Clinical Manifestations ... • CSF: Oligoclonal ... Treatment: • ... #treatment #neurology