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differential rheumatology management lupus disorders ana antibody antinuclear druginduced erythematosus laboratory nuclear patterns anemia antiphospholipid apls arthritis classification clinicopathology clues
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Algorithm INDICATIONS ... evaluation or workup ... 1,500 cells/µL Workup ... #Differential #diagnosis ... #hematology #eosinophilia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... smear, HIV/HCV testing ... test, ANA (e.g., SLE ... #Causes #Workup
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... • Immunologic Workup ... Discontinuation of causal ... • Immunologic Workup ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Manifestations: Malar rash ... • Immunologic Workup ... Positive in 60-80% of cases ... Erythematosus #Diagnosis
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... deficiency Work ... #Differential #Diagnosis ... #Algorithm #Causes
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody Testing ... Smith, Sm/RNP, Scl ... Antinuclear #Antibody #Testing ... #differential #diagnosis ... #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
everywhere) 2) A rash ... many differential diagnoses ... 6) An annular rash ... search ANA and aPL ... #sle #clues #system
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... genotypes): SS, SC, SE ... #Algorithm #workup ... #hematology #testing
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
: Blast crises ... lymphocytic lymphoma (SLL ... Lymphocytic Lymphoma (SLL ... #Leukemia #Hematology ... #Oncology #Diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... (to support a diagnosis ... Arthritis #laboratory #workup ... #diagnosis #testing ... #Rheumatology
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