10 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
ascending limb Gitelman ... tubule Liddle syndrome ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Hypernatremia Classification and Features According to Volume Status
 - Hypervolemic hypernatremia - Cushing's syndrome, Primary hyperaldosteronism,
Hypernatremia Classification ... hypernatremia - Cushing's syndrome ... #Features #Diagnosis ... #Comparison #Table ... #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Autoimmune disease ... #Syndrome #diagnosis ... #nephrology #management ... #pathophysiology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Fractional excretion of Cl ... dominant kidney disease ... #Syndrome #Diagnosis ... #Workup #nephrology
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
Haemolytic-uraemic syndrome ... Nephrotic syndrome ... #nephrology #pathology ... #comparison #table ... #diagnosis #microscopy
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... • Diagnosis of ... Inhibitors of Na+K+2Cl ... Excretion #Diuresis #Nephrology ... #Medications #Table
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Shock, Autoimmune disease ... Etiology: • Pathophysiology ... factor PRES Diagnosis ... circulation: MCA ACA ... #neurology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... advanced liver disease ... Pathophysiology: ... Classification: ... #Hepatology #Nephrology
Hyperthermic Toxidromes
Five toxidromes may present with overlapping features: hyperthermia, rhabdomyolysis, altered mental status/seizures.
 • Sympathomimetic -
of muscarinic Ach ... • Serotonin Syndrome ... pharmacogenetic disease ... Hyperthermic #Toxidromes #comparison ... #table #diagnosis