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diagnosis differential causes hyperkalemia diuretics table acidosis algorithm aniongap asthma bipolar bpd disorder diuresis druginduced excretion hypokalemia lithium maintenance management
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... pathophysiology #pharmacology ... #potassium #medications
Summary of Diuretic Agents Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction CARBONIC ANHYDRASE
Agents Subclass, Drug ... Chlorthalidone POTASSIUM-SPARING ... #Diuretics #Medications ... #Pharmacology # ... summary #table #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... reactions Common Drugs ... • NSAIDs • ACE ... Medications 2. ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... reactions Common Drugs ... • NSAIDs • ACE ... Medications 2. ... #high #nephrology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis Causes of High-anion Gap Acidosis: • Lactic acidosis
Causes of High-anion ... Acidosis Causes of High-anion ... Potassium-sparing ... ACE-Is and ARBs ... diagnosis #causes #nephrology
Asthma Maintenance Therapy - Stepwise Approach Low dose ICS -> Low dose ICS/LABA or Med/High dose
ICS/LABA or Med/High ... primary maintenance drug ... remember that all ... before increasing medication ... Therapy #Management #Pharmacology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Inhibitors of Na+K+2Cl ... Loop Diuretics; High-Ceiling ... Excretion #Diuresis #Nephrology ... #Pharmacology # ... Medications #Table
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
1.6, low urine Cl ... < 0.7, high urine ... correcting serum potassium ... Other medications ... differential #algorithm #nephrology
Lithium Therapy for Bipolar Disorder Toxicity Levels: - Mild (1-1.5 mEq/L) - Moderate (1.6-2.5
and diuretics all ... Lithium is a medication ... If levels are high ... include these drugs ... BPD #Toxicity #Pharmacology
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