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management hyperkalemia hematology cardiology differential druginduced nephrology blood causes heartfailure hfref high lupus oncology product reactions schf apml binder cardiomyopathy
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... • Exogenous (KCL ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Heart Failure (HFrEF) Treatment - GDMT for stage C For patients with Heart Failure with REDUCED
Failure (HFrEF) Treatment ... recommended by the ACC ... /ambcarerx #CHF ... #HFrEF #Pharmacology ... #Management #Treatment
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... INDICATION: Treatment ... patients with CKD, HF ... ACE inhibitors, ... #Hyperkalemia #Pharmacology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Differential Diagnosis ... • NSAIDs • ACE ... • Recent IV potassium ... Food - Avoid in CRF ... #causes #potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Differential Diagnosis ... • NSAIDs • ACE ... • Recent IV potassium ... Food - Avoid in CRF ... #causes #potassium
Heart failure with Reduced Ejection Fraction (HFrEF) Clinical Presentation 1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
un lymphatic Diagnostic ... endomyocardial biopsy Pharmacology ... : • ACE Inhibitors ... #heartfailure #diagnosis ... management #cardiology #pharmacology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Medications: K+, ACEi ... Na delivery): CHF ... Ca-gluconate or 1g CaCl ... #potassium #nephrology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... Triggers: ATRA treatment ... sepsis), PE, DAH, CHF ... Renal Failure Treatment ... #management #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE ... constitutional symptoms • Treatment ... life-threatening • Treatment ... comparison #table #rheumatology ... #diagnosis #management
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
Differential Diagnosis ... May have typical HF ... • Avoid ARB/ACE-I ... GDMT meds (e.g., ACE ... management #cardiology #treatment
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