12 results
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... Treatment of TLS ... #TumorLysis #Syndrome ... #management #oncology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... 6L/day) • For hyperkalemia ... #Syndrome #TLS ... #oncology #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
have fever - ACS ... leukapheresis - TLS ... hydration - Hyperkalemia ... #Syndrome #TLS ... #diagnosis #management
Treatment of hyperkalemia via kaliuresis 
step 1 = volume resuscitation if hypovolemic
step 2 = consider fludrocortisone
step
Treatment of hyperkalemia ... #kaliuresis #management ... #criticalcare # ... #diuresis #nephrology ... #algorithm
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Acidosis, Cell Lysis ... (TLS, rhabdo/crush ... acidosis), CK+LDH (lysis ... Ca-gluconate or 1g CaCl ... #nephrology #K
The rationale for aggressive treatment of generalized status epilepticus was described previously here.  In short,
for aggressive treatment ... cause aspiration, hyperkalemia ... #Management #Neurology ... #CriticalCare # ... Refractory #Seizures #Algorithm
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Rhabdomyolysis Treatment ... #diagnosis #nephrology ... #management #pathophysiology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... - Compartment syndrome ... HIV, Influenza, TSS ... Differential #Diagnosis #Management ... #nephrology
Gitelman Syndrome - Management
Treatment includes
 - Electrolyte replacement - K & Mg, preferably Cl salts
- Management Treatment ... Mg, preferably Cl ... In persistent hypokalemia ... #Management #Treatment ... #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
• Metabolic alkalosis ... irrigation • Management ... Inhibitors of Na+K+2Cl ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology