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differential leukemia lymphocytic management blood classification criteria diffuse disorders erythematosus hemeonc hemophagocytic immunecompromised immunocompromised lupus lymphohistiocytosis lymphoma markers mds myelodysplasia
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Hepatomegaly, Lymphadenopathy ... Confusion Classic lab ... : ↑↑ ferritin, Anemia ... Thrombocytopenia, Neutropenia ... #hematology #criteria
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Age > 50 • Chronic ... #LAD #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology ... #Oncology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Algorithm Acute ... ) - PAS, TdT Lymphadenopathy ... - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... Blood #Disorders #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... or functional neutropenia ... • HSM • Fevers ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Fevers > 100.5 ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Presentation: • Lymphadenopathy ... • Dyspnea • Fever ... Weight loss • Anemia ... classification #hematology ... #oncology #management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... ) B symptoms → fevers ... PRCA, autoimmune neutropenia ... #Leukemia #oncology ... #hematology #hemeonc
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... CNS Infection Neutropenia ... Bronchitis • Chronic ... #Algorithm #Causes ... #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Myeloproliferative Disease • Neutropenia ... compounds, alcohol, lead ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic ... cyclophosphamide) • Hodgkin ... #Rheumatology
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