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pharmacology management ckd coxinhibitor cyclooxygenase ebm intravenous iv lidocaine nephrology nsaid overview pain renalcolic review selectivity urology visualabstract advil algorithm
NSAID Pharmacology - Amy Chung, MD, MSc @AmyChung #NSAIDs #Pharmacology #COX #Cyclooxygenase
NSAID Pharmacology ... @AmyChung #NSAIDs ... #Pharmacology #COX
NSAID Selectivity Spectrum COX-2 Selective NSAID - Celecoxib • Increased risk for CV events • Decreased risk
NSAID Selectivity ... Spectrum COX-2 ... Selective NSAID ... Increased affinity for COX ... retain activity COX
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 Primary Hyperoxaluria - A radiograph of the abdomen showed stones in the kidneys, bladder, and left
Primary Hyperoxaluria ... Radiology #urology #Hyperoxaluria ... PrimaryHyperoxaluria #AGXT
Therapeutic Advantages and Disadvantages of some NSAIDs Salicylates: Aspirin, Salicylate salts, Diflunisal Acetic acids: Indomethacin, Sulindac, Tolmetin Propionic acids:
Disadvantages of some NSAIDs ... Meclofenamic acid, COX ... Celecoxib #NSAIDs
Calcium Oxalate (CaOx) Stone Diet • All - Increase Water Intake • Relative Hypercalciuria
Calcium Oxalate (CaOx ... Proteins • Relative Hyperoxaluria ... d) • Enteric Hyperoxaluria ... Calcium #Oxalate #CaOx
Celecoxib. COX-2-specific NSAID, lower thrombembolic risk than rofecoxib and valdecoxib. Gabapentin - antiepileptic drug also used for
COX-2-specific NSAID ... Celecoxib #Celebrex #NSAID
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
eosinophiluria) • Drugs (NSAlDs ... Multiple myeloma • Hyperoxaluria
Management of Pediatric Kidney Stones Acute Managment: • Pain relief: NSAIDs, opioids • Facilitating passage of stone:
• Pain relief: NSAIDs ... Rx: • PRIMARY HYPEROXALURIA
NSAIDS and COX Selectivity Relative selectivity of some commonly used NSAIDs. Data shown as the logarithm of
NSAIDS and COX Selectivity ... commonly used NSAIDs ... COX-1 Selectivity ... Ibuprofen, Fenoprofen COX ... Etodolac #NSAIDs
Benign Prostatic Hyperplasia: Pathogenesis and Medications Aging -> Increased Testosterone -> Testosterone metabolized into DHT by type
Improved LUTS - NSAlDs ... -> Decr COX activity
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