11 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
and first-line treatment ... Microangiopathy #thrombocytopenic ... #purpura #TTP # ... HemolyticUremicSyndrome #HUS #thrombocytopenia ... Diagnosis #Table #Hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Thrombocytopenic ... Purpura (TTP) ... TTP Thrombotic #Thrombocytopenic ... #Purpura #management ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Polycythemia Vera • Chronic ... : • Acute or Chronic ... effect following treatment ... following EtOH induced thrombocytopenia ... Algorithm #Causes #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... Petechiae • Purpura ... DITMA) - MAHA + Thrombocytopenia ... coagulopathy - Thrombocytopenia ... anticoagulants - Thrombocytopenia
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Heparin Induced Thrombocytopenia ... consumption → thrombocytopenia ... emcrit.org/ibcc/thrombocytopenia ... Heparin #Induced #Thrombocytopenia ... Diagnosis #Management #Treatment
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Chronic Lymphocytic ... Symptoms of anemia or thrombocytopenia ... with anemia or thrombocytopenia ... uw_IMresidency #CLL #Chronic ... Leukemia #oncology #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
easy bruising to purpura ... (Petechial or purpuric ... leukopenia, anemia, and thrombocytopenia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Neutropenia, anemia, thrombocytopenia ... microglobulin Treatment ... leukemia #CLL #Chronic ... workup #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... with a relatively chronic ... activity • ↓ LAP Score ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... Marrow Failure • Chronic ... IDUS) • Immune Thrombocytopenia ... factor (GCSF) treatments ... Syndromes #diagnosis #hematology