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diagnosis hematology oncology mds myelodysplastic activation algorithm causes chronic common cvid differential hemeonc hemophagocytic hlh hypogammaglobulinemia immunodeficiency immunology leukemia lymphocytic
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... infections/fevers • Thrombocytopenia ... #hematology #diagnosis ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... , thrombocytopenia ... aplasia • ITP ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... cytopenias (usually anemia ... Allogeneic stem cell ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... platelet count (thrombocytopenia ... • Aplastic Anemia ... IDUS) • Immune Thrombocytopenia ... #diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
haemophagocytic lymphohistiocytosis ... hemophagocytic lymphohistiocytosis ... with leukopenia, anemia ... , and thrombocytopenia ... #Diagnosis #Management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... specifically immune thrombocytopenia ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... - Cytopenias (anemia ... , thrombocytopenia ... Hemophagocytic #Lymphohistiocytosis ... #Hematology #HemeOnc
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