18 results
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... count and platelet ... Gplb receptor • Thrombcytopenia ... Von Willebrand Disease ... #disorders #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... History: - Prior platelet ... PT, aPTT(liver disease ... bypass), LFT (liver disease ... Causes #Workup #hematology
PLATELETS Mnemonic for Causes of Thrombocytopenia

P - Platelet Disorders (DIC, ITP, TTP)
L - Leukemia, Lymphoma
A -
PLATELETS Mnemonic ... for Causes of Thrombocytopenia ... Spleen L - Liver Disease ... Mnemonic #Acronym #Thrombocytopenia ... Differential #Diagnosis #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... Laboratory • Normal platelet ... count (mild thrombocytopenia ... VonWillebrand #Disease ... #Diagnosis #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Diagnosis Algorithm Thrombocytopenia ... Sequestration Disordered Platelet ... ASA) • Renal Disease ... Von Willebrand's Disease ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
RBC's secondary to platelet ... inflammation • Thrombocytopenia ... • Platelet defects ... Primary Causes: - Thrombocytopenia ... Differential #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Consider sickle cell disease ... with or without platelet ... , Hemoglobin H disease ... Schistocytes, thrombocytopenia ... Algorithm #workup #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... Findings in DIC: • Platelet ... - Platelet rich ... • Severe Liver Disease ... treatment #management #hematology
Platelet Disorders - Differential Diagnosis Framework

Qualitative Defects:
 • Adhesion
 • Aggregation
 • Secretion

Quantitative Defects:
 • Production:
Platelet Disorders ... Production: Liver disease ... , marrow disease ... Differential #Diagnosis #hematology ... #thrombocytopenia
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Symptoms of anemia or thrombocytopenia ... chemotherapy for low-risk disease ... with anemia or thrombocytopenia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc