58 results
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
Idiopathic Thrombocytopenic ... children) • Platelets ... extremely low platelet ... #Purpura #Thrombocytopenia ... Diagnosis #Overview #Hematology
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Differential Diagnosis Platelet ... Reactive: • Anemia ... Chronic Myeloid Leukemia ... Diagnosis #causes #Platelets ... #hematology
PLATELETS Mnemonic for Causes of Thrombocytopenia

P - Platelet Disorders (DIC, ITP, TTP)
L - Leukemia, Lymphoma
A -
for Causes of Thrombocytopenia ... ITP, TTP) L - Leukemia ... A - Aplastic Anemia ... Mnemonic #Acronym #Thrombocytopenia ... Differential #Diagnosis #Hematology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... , Large platelets ... chain IIA • Thrombocytopenia ... fibrinogen) • Thrombocytopenia ... differential #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Chronic Myelogenous Leukemia ... Non malignant hematologic ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Features of hematologic ... hepatomegaly • Labs: anemia ... , ↑ MCV, ↑/↓ platelets ... Diagnosis #Algorithm #hematology ... #WBC #Leukemoid
Causes of Thrombocytopenia.
Platelet counts may be depressed because of decreased production or due to increased platelet
Causes of Thrombocytopenia ... Platelet counts ... due to increased platelet ... #Diagnosis #Hematology ... #Thrombocytopenia
Approach to suspected Heparin-Induced Thrombocytopenia (HIT)

 • Suspected HIT Algorithm
 • "4 T's" clinical probability score:
Heparin-Induced Thrombocytopenia ... score: - Thrombocytopenia ... (platelet count ... Timing of onset of platelet ... #HIT #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Heart Valve) #Thrombocytopenia ... Algorithm #Causes #Hematology
Algorithm for diagnosis of familial thrombocytopenia. Platelet size, best determined by review of the peripheral smear,
diagnosis of familial thrombocytopenia ... Platelet size, best ... #Diagnosis #Hematology ... #Familial #Thrombocytopenia