53 results
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Epithelial Cells Renal ... ascending limb Gitelman ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... autosomal recessive salt-losing ... thiazide-sensitive sodium-chloride ... Pathophysiology #nephrology ... #diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
- Differential Diagnosis ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #Differential #Diagnosis ... #Algorithm #nephrology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential Diagnosis ... Osmolarity 3) Urine Sodium ... High Uric Acid → renal ... salt wasting By ... #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
- Differential Diagnosis ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #Differential #Diagnosis ... #Algorithm #Nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
- Differential Diagnosis ... perspiration Renal ... insipidus Excessive salt ... #Causes #nephrology ... #sodium #high
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
- Differential Diagnosis ... Renal Causes of ... Bartter syndrome and Gitelman ... #differential #diagnosis ... #causes #nephrology
General approach to AKI - Checklist

Urine electrolytes & FENa - Previously, it was believed that urine
believed that urine sodium ... fractional excretion of sodium ... and intrinsic renal ... performance for diagnosing ... AcuteKidneyInjury #Nephrology
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
• Increased renal ... Hypoperfusion • Reduced renal ... hypertrophy • Sodium ... release • ↓ Cl ... pathophysiology #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... • Hypokalemia (renal ... #Syndrome #diagnosis ... #nephrology #management