26 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
(renal potassium ... Sjögren syndrome, Renal ... Rhabdomyolysis Treatment ... #Syndrome #diagnosis ... #nephrology #management
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... Extra-renal Losses ... Bartter syndrome, Gitelman ... potassium #low #nephrology
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
- Differential Diagnosis ... Bartter syndrome and Gitelman ... with secondary, hypocalcemia ... #differential #diagnosis ... #causes #nephrology
Gitelman Syndrome - Management
Treatment includes
 - Electrolyte replacement - K & Mg, preferably Cl salts
Gitelman Syndrome ... Mg, preferably Cl ... food - Liberal salt ... In persistent hypokalemia ... #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential Diagnosis ... • Renal tubular ... Bartter's syndrome, Gitelman's ... #differential #diagnosis ... algorithm #causes #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... autosomal recessive salt-losing ... H+ secretion → Hypokalemia ... Pathophysiology #nephrology ... #diagnosis
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... Diagnosis Algorithm ... Bartter's syndrome, Gitelman's ... syndrome #Hypokalemia ... #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
- Differential Diagnosis ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #Differential #Diagnosis ... #Algorithm #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... • Cell shift: Hypokalemic ... Bartter syndrome, Gitelman ... differential #algorithm #diagnosis ... #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Epithelial Cells Renal ... ascending limb Gitelman ... receptor Distal renal ... Defects #Kidney #Nephrology ... #Diagnosis #Differential