14 results
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... Laboratory #Metabolism #ASTALT ... #AlkPhos #Bilirubin ... Pathophysiology #Diagnosis
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
LFTs) - Normal Values ... Alkaline phosphatase (AlkP ... Indirect bilirubin ... LFTs #Laboratory #Values ... Interpretation #diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... week • Direct bilirubin ... normal AST/ALT AST ... Elevation: • Bilirubin ... #chemistry #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... week • Direct bilirubin ... be abnormal AST ... Elevation: • Bilirubin ... #differential #diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Defects, Drugs, Liver ... - Unconjugated Bilirubin ... #Differential #Diagnosis
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... >1.5, and both values ... • Serum total bilirubin ... ) or metabolic liver ... #diagnosis #Alcoholic
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... - Serum total bilirubin ... ) or metabolic liver ... Possible drug-induced liver
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... or sed rate): Value ... w/differential diagnosis ... GCA, but normal values ... Start steroids if
Pancreatitis management checklist 
Evaluation to guide etiology & management 
 - RUQ ultrasound 
 - Calcium
Triglyceride level - Liver ... markedly elevated bilirubin ... Pain control - Start ... Pancreatitis #Checklist #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
juvenile idiopathic arthritis ... juvenile idiopathic arthritis ... thrombocytopenia • Liver ... ↑ AST ↑ ALT ↑ bilirubin ... Activation #Syndrome #Diagnosis