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Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
/ALT elevation > ... Alk phos • ALT ... • R value = (ALT ... + ULN ALT) / (alkaline ... Transaminitis #diagnosis #differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... • Severe - ALT ... • Moderate - ALT ... Others • Mild - ALT ... > ALT or AST):
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT ... /ULN ALT) / (Alk ... to liver than ALT ... • ALT: Specific ... chemistry #diagnosis #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Algorithm Severe ALT ... HELLP Moderate ALT ... • Others Mild ALT ... #LiverEnzymes #Differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... to liver than ALT ... • ALT: Specific ... • AST/ALT > ALP ... injury #hepatitis #differential
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Liver Injury - Differential ... /ALT compared with ... /ALT) Hepatocellular ... Liver Injury Differential ... Liver #Injury #Differential
Etiology of Acute Liver Failure – bolded entities are most likely to cause AST/ALT in the
likely to cause AST ... /ALT in the 1000s ... Transaminitis #Differential
Causes of Apparent Life Threatening Event (ALTE) - Differential Diagnosis Algorithm Cardiac: • Congenital Heart Disease •
Threatening Event (ALTE ... ) - Differential ... LifeThreatening #Event #ALTE ... #BRUE #Differential
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... CPK 5X ULN • AST ... /ALT Elevation 4 ... > ALT) • AKI: ... Rhabdomyolysis #Differential
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Findings: • ↑AST ... /ALT (5-10x ULN) ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential
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