21 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Algorithm for Investigation ... of Abnormal Coagulation ... DrEricStrong #Algorithm ... #Coagulation #Abnormal ... Hematology #Diagnosis #Workup
Coagulation Protein Tests (PT and PTT)

#Coagulation #Tests #PTT #algorithm #differential #pathophysiology
Coagulation Protein ... Tests (PT and PTT ... ) #Coagulation ... #Tests #PTT #algorithm
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
(DIC) Overview ... • Prolonged PT/PTT ... Manifestations of DIC ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation ... (DIC) Platelet ... aggregation PT, aPTT ... consumption of coagulation ... small vessels #DIC
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... Congenital intrinsic coagulation ... intravascular coagulation ... (DIC) c. ... differential #hematology #coagulation
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
INR), Prolonged PTT ... INR), Prolonged PTT ... (INR), Normal PTT ... Differential #Diagnosis #Algorithm ... Causes #Hematology #coagulation
Chest Pain - Diagnosis and Workup Algorithm

History and Exam
Acute life-threatening causes:
 • Acute myocardial infarction
 •
Diagnosis and Workup ... Algorithm History ... LET, lipase, PT. aPTT ... Pain #Diagnosis #Algorithm ... #workup
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Differential Diagnosis Algorithm ... /uL Initial Workup ... iron studies, PT/aPTT ... Differential #Diagnosis #Algorithm ... #hematology #workup
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... intravascularcoagulation (DIC ... #Abnormal #PT #aPTT ... differential #hematology #coagulation
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC ... Intravascular #Coagulation