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Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... antiglobulin test, PT ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal •
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... mild cases) • PT ... Chronic Management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... causes #treatment #management
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Evaluate an Abnormal APTT ... Step 1: Is the PT ... or APTT Artifactually ... Prolonging the PT ... or APTT?
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm aPTT: Intrinsic / Final PT: Extrinsic / Final By
Approach to Elevated aPTT ... / PT - Differential ... Intrinsic / Final PT ... #Elevated #aPTT ... #PT #INR #Algorithm
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
Tests - Prolonged PT ... - Prolonged aPTT ... and Prolonged PT ... - Prolonged aPTT ... Coagulation #Abnormal #APTT
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged PT ... • Prolonged PT ... • Prolonged PT ... , Normal PT (INR ... , Normal PT (INR
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... Prothrombin Time (PT ... typically prolong PT ... antibody Prolonged PT ... #Abnormal #PT
Coagulation Protein Tests (PT and PTT) #Coagulation #Tests #PTT #algorithm #differential #pathophysiology
Protein Tests (PT ... and PTT) #Coagulation ... #Tests #PTT #algorithm
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Prothrombin Time (PT ... Thromboplastin Time (PTT ... Prothrombin Time (PT ... thematttsai #PT ... #PTT #Prothrombin
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