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diagnosis cardiology rheumatology algorithm anemia causes dermatology joint pain agglutinin arthritis cold conditions dehydrogenase disease elevated extrarticular framework infections infectiousdiseases
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
, Infective endocarditis ... , Infective endocarditis ... • Prosthetic valve ... annulus valve: ... Regurgitation #differential
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... Pyogenic/focal infection ... arthritis • Infective ... with profound hemolysis ... #Patterns #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... mechanical cardiac valve ... inclusions - If infection ... bartonella (oroya fever ... Algorithm #workup #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
quinine, etc) - Viral ... infiltration: malignancy, infection ... - Mechanical: valve ... replacement, endocarditis ... Diagnosis #Framework #hematology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Involves aortic and mitral ... night sweats, fever ... Marantic (NTBE) Differential ... Paradoxical emboli via ASD ... Persistent bacteremia/fevers
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... - Prosthetic valves ... ratio < 1.5) from viral ... • Toxins • Infection ... myocarditis, rheumatic fever
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
infection • ... Subacute bacterial endocarditis ... Cardiovascular system • Mitral ... infection, Amyloidosis ... #joint #pain #differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... CTD (SLE) - Viral ... mountain spotted fever ... • Bacterial endocarditis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
infection, autoimmune ... Infection Clinical ... younger pts) Differential ... Symptoms: High fevers ... #anemia #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... - Trauma - Infection ... Red Flags: • Fever ... Schonlein Purpura - Endocarditis ... Microscopic) - Viral
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