43 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
thiazide-sensitive sodium-chloride ... in the distal tubule ... H+ secretion → Hypokalemia ... Pathophysiology #nephrology ... #diagnosis
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium ... distal convoluted tubule ... ratio 0.5%) Differential ... #Syndrome #diagnosis ... #nephrology #management
Differential Diagnosis of Acute Kidney Injury 

#Diagnosis #Nephrology #AKI #Acute #KidneyInjury #Causes #Differential #Workup #Algorithm #Ddxof
Differential Diagnosis ... of Acute Kidney ... Injury #Diagnosis ... #Nephrology #AKI ... #Workup #Algorithm
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Diagnosis Algorithm ... Bartter syndrome, Gitelman ... #Differential # ... potassium #low #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Once pseudohypokalemia is ruled out, causes of hypokalemia can be
- Differential ... Diagnosis Algorithm ... #Differential # ... #Causes #workup ... #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
ascending limb Gitelman ... cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
Hypocalcemia Workup ... - Differential ... Hyperphosphatemia, Acute ... #Workup #Differential ... #nephrology #calcium
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
- Differential ... Diagnosis Increased ... glycosides • High acute ... blockers - MCW Nephrology ... #Differential #
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Hypomagnesemia - Differential ... Diagnosis Renal ... Bartter syndrome and Gitelman ... with secondary, hypocalcemia ... #nephrology #magnesium
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
- Differential ... Diagnosis Algorithm ... Bartter's syndrome, Gitelman's ... #differential # ... #causes #nephrology