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differential algorithm potassium syndrome management pathophysiology table urine causes chloride defects diuresis diuretics epithelial excretion hyperkalemia inherited low medications metabolic
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
nephron → - ↑ K+ ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... Pathophysiology #nephrology ... #diagnosis
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
differentiating kidney ... - Metabolic Alkalosis ... Bartter syndrome, Gitelman ... #diagnosis #Algorithm ... differential #potassium #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... ↑ Aldosterone: Kidney ... Bartter syndrome, Gitelman ... differential #algorithm #diagnosis ... #nephrology
Gitelman Syndrome - Diagnosis and Workup Blood Work: - Hypokalemia - Hypomagnesemia - Metabolic Alkalosis - Elevated
Gitelman Syndrome ... Blood Work: - Hypokalemia ... Hypomagnesemia - Metabolic Alkalosis ... Inappropriate renal K+ ... #Workup #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
distal convoluted tubule ... Hypochloremic metabolic alkalosis ... Rhabdomyolysis Treatment ... #Syndrome #diagnosis ... #nephrology #management
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
Inherited Defects in Kidney ... syndrome - Na-K- ... cotransporter, K ... ascending limb Gitelman ... #Nephrology #Diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
• Kidney loss ... Bartter syndrome, Gitelman ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential #diagnosis
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Calcium 2-3g IV Ca-gluconate ... definitive guide to diagnosis ... #Diagnosis #Management ... #nephrology #K
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... plasma insulin (treatment ... diuretic use), Gitelman's ... #differential #diagnosis ... #nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
• Metabolic alkalosis ... disequilibrium syndrome • Diagnosis ... Inhibitors of Na+K+ ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology
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