11 results
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
- Differential Diagnosis ... diuresis (see Polyuria ... mannitol, glucosuria Low ... Urine Osmolality ... #Nephrology #Differential
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Based Approach to Hyponatremia ... Hypothyroidism, Low ... Cirrhosis, Nephrotic syndrome ... #algorithm #diagnosis ... #sodium #low #nephrology
Causes of Polyuria - Differential Diagnosis
Excess Intake of Water:
 • Primary polydipsia (a.k.a. "psychogenic polydipsia")
 •
- Differential Diagnosis ... • Central Dl (Low ... Mimics (↑ urine ... - Strong Medicine ... #Causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Normal/low ... , Gitelman syndrome ... Urine chloride is ... #nephrology #differential ... #diagnosis
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... volume contracted: urine ... volume expanded: urine ... #Differential #Diagnosis ... #Causes #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Differential Diagnosis ... Algorithm 1) Check Urine ... • Euvolemic (Low ... , Cushing syndrome ... Workup #Algorithm #nephrology
Hepatorenal Syndrome Diagnosis
 • ↑ in serum Cr of ≥ 0.3mg/dL above baseline
Hepatorenal Syndrome ... Diagnosis • ↑ ... type 2 HRS) • Low ... urine Na+ (<10 ... #nephrology #criteria
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
volume-based algorithm Urine ... can be high or low ... Cirrhosis, Nephrotic syndrome ... #differential #diagnosis ... table #sodium #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... alkalosis • Normal or low ... Hypocalciuria (spot urine ... • Congenital chloride ... #diagnosis #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... Heat injury, Heat stroke ... Weakness - Dark urine ... Hyperuricemia • Hyponatremia ... causes #treatment #nephrology