12 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
: Proximal tubule ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... • Central Cord Syndrome ... #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Defects in Kidney Tubule ... transporter Bartter syndrome ... ascending limb Gitelman ... Liddle syndrome ... Defects #Kidney #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... distal convoluted tubule ... #nephrology #management ... #pathophysiology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... clinical context and signs ... • Cardio-renal syndrome ... Acute #Kidney #Injury ... Differential #Diagnosis #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
diuretics after renal tubule ... indicates a renal tubule ... furosemide-like lesion) • Gitelman ... syndrome (defective ... Diagnosis #Causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter syndrome ... , Gitelman syndrome ... in the proximal tubule ... urine #Algorithm #nephrology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
Immune mediated injury ... disease - Alport syndrome ... pain hematuria syndrome ... hematuria • Signs ... #nephrology #renal
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
• Symptoms and signs ... below the site of injury ... below the site of injury ... MCTD, Sjogren syndrome ... disorders #diagnosis #neurology