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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE #hematology ... #rheumatology #
Pathophysiology of Hemolytic Anemia
 - Defects in RBC internal contents (thalassemia, hemoglobinopathies, and metabolic defects)
 -
Hemolytic Anemia - Defects ... and metabolic defects ... ) - Defects in ... rnembranes - Defects ... Hemolytic #Anemia #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... anemia, Rebound effect ... Inflammatory Conditions: Rheumatologic ... Diagnosis #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Non malignant hematologic ... conditions: • Rebound effect ... ITP • Rebound effect ... states • Non-hematologic ... Algorithm #Causes #Hematology
Atrial Septal Defect (ASD) with Shunting on Echocardiogram with Contrast (a4c)

An elderly patient with dyspnea -
Atrial Septal Defect ... (ASD) with Shunting ... with dyspnea - ASD ... Atrial #Septal #Defect ... #ASD #Echocardiogram
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
Sheet Novel (or Direct ... #Prescribing #hematology ... #management #Direct
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Extrinsic RBC Defects ... Intrinsic RBC Defects ... : Membrane defects ... Diagnosis #Algorithm #hematology
ASD on Bubble Contrast Echocardiogram (a4c)
A patient with an anterior STEMI (take a look at the
ASD on Bubble Contrast ... previously undiagnosed ASD ... you close the defect ... atrial #septal #defect ... #ASD #Bubble #Contrast
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Thrombocytopenia • Platelet defects ... PURPURA: Platelet Defects ... syndrome Coagulation Defects ... Differential #Diagnosis #hematology ... #rheumatology #
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Qualitative Platelet Defects ... Bernard-Soulier Syndrome • Defect ... Thrombasthenia • Defect ... Related Disorder • Defect ... differential #diagnosis #hematology