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hematology differential aids apml associated cauda caudaequina causes chronic clinical cll dementia differentiation disorder equina half hand hiv leukemia lymphocytic
One and a Half Syndrome on Physical Exam This 28 year old patient presented to clinic with
One and a Half Syndrome ... An APD was noted ... the follow up video ... the hospital, diagnosed ... ophthalmology #neurology
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 Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
spine L1-L5 Symptoms ... so-called ‘red flag’ symptoms ... Differential Diagnosis ... decreased rectal tone ... #causes #neurology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Splenic Marginal Zone ... et diutinum Neurologic ... WAIHA • CAD • PCH ... #Differential #Diagnosis ... #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... -48% depending on ... : >3 symptoms, or ... fluid overload, PCC ... management #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... phenomenon CLL Diagnosis ... • Richter’s Syndrome ... Transform to DLBCL, PML ... #workup #oncology
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
• Depressive symptoms ... Diagnosis: MRI ... signal intensity on ... The clinical syndrome ... dementia #AIDS #Neurology
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