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differential hematology causes erythematosus hemolytic sle systemic types algorithm allergic allergy cryoglobulinemia cryoglobulins definitions dermatology extravascular hemolysis hypersensitivity intravascular monoclonal
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Autoimmune Hemolytic anemia ... Target: Antigen-Ab ... • Ex: Systemic Lupus ... #Types #Classification ... #Diagnosis #Definitions
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... hemolysis, deficiency anemia ... , Vasculitides, ... syndrome, POEMS • Reaction ... #Differential #Diagnosis
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... - systemic lupus ... dermatomyositis #Size #Classification ... #Diagnosis #Rheumatology ... #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANA, anti-Smith Ab ... Skin Disease Classification ... and psychosis • AB ... lymphopenia, low PLT • Anemia ... #Rheumatology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Transfusion reactions ... #causes #classification ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... Other: Transfusion reaction ... usually IgG) (e.g. lupus ... #hematology #anemia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Butterfly rash, Vasculitis ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... disease, drug reactions ... #rheumatology # ... classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... fever • Drug reactions ... #Differential #Diagnosis ... #hematology #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Labs/Diagnosis: ... (e.g. systemic lupus ... Cryoglobulins #diagnosis ... #types #classification ... #rheumatology #
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