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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... : • Classic Acromegaly ... resistance pseudo-acromegaly ... or refractory cases ... thakre_anuj) #Acromegaly
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... GH excess prior ... plate fusion -> acromegaly ... • Other rare causes ... of acromegaly include
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... growth hormone (GH ... #Acromegaly #Signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... - Giantism or acromegaly ... GrowthHormone #GH
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Puberty Onset • GH ... Resistance • Acromegaly ... endocrinology #causes
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
growth Hirsutism causes ... Cushing's Syndrome, Acromegaly ... tumors Hirsutism causes ... Cushing's Syndrome, Acromegaly
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Causes of Proximal ... Endocrinopathies - Acromegaly ... #differential #causes
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Prolactin • GH ... endocrinology #causes
Secondary causes of Hypertension
 • Medications, Drugs, Chemo: NSAIDS, Steroids, CNI, Alcohol, Cocaine, OCP, Licorice, MAOI,
Secondary causes ... Other Endocrine causes ... Hyperparathyroidism, Acromegaly ... low renin HTN causes ... #Secondary #causes
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Pseudo-hypoparathyroidism • Acromegaly ... endocrinology #causes