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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... : • Classic Acromegaly ... Differential Diagnosis ... syndrome) Diagnosis ... #Diagnosis #Management
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... GH excess prior ... plate fusion -> acromegaly ... rare causes of acromegaly ... Overproduction #diagnosis
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... growth hormone (GH ... #Acromegaly #Signs ... #Symptoms #Diagnosis
Acromegaly Testing Algorithm
INDICATIONS FOR TESTING:
 • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing ... Growth Hormone (GH ... ARUPConsult @ARUPLabs #Acromegaly ... Testing #Algorithm #diagnosis
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
- Differential Diagnosis ... Puberty Onset • GH ... Resistance • Acromegaly ... #Differential #Diagnosis
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... - Giantism or acromegaly ... GrowthHormone #GH
#ACROMEGALY #management #algorithm #treatment
#ACROMEGALY #management
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
- Differential Diagnosis ... Cushing's Syndrome, Acromegaly ... Cushing's Syndrome, Acromegaly ... #Differential #Diagnosis
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
- Differential Diagnosis ... Prolactin • GH ... #Differential #Diagnosis
Acromegalic Hand: Markedly enlarged hand resulting from excess growth hormone. For reference
purposes, the comparison hand is
Acromegalic Hand ... Clinical #Photo #Acromegaly ... #Acromegalic #Hand